Memory Traces: Experimental Separation by Cycloheximide and Electroconvulsive Shock

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Science  03 Nov 1972:
Vol. 178, Issue 4060, pp. 518-520
DOI: 10.1126/science.178.4060.518


Mice given cycloheximide or saline were trained with a single trial. Electroconvulsive shock was administered to both groups at various times after training. Cycloheximide led to memory that decayed with time. Cycloheximide plus electroconvulsive shock produced complete amnesia at times when neither treatment alone produced amnesia. Only two types of processes appear to support memory storage in our study.