Hemoglobin Lepore Trait: Globin Synthesis in Bone Marrow and Peripheral Blood

Science  10 Nov 1972:
Vol. 178, Issue 4061, pp. 623-625
DOI: 10.1126/science.178.4061.623


There was decreased synthesis of the β-globin chain in the peripheral blood, and equal synthesis of α- and non-α-chains in the bone marrow of three patients with hemoglobin Lepore trait, similar to the findings in patients with heterozygous β-thalassemia. There is a relative instability of the synthetic mechanism for normal β-chain in these patients.