Transfer Factor: Delayed Hypersensitivity to Schistosoma mansoni and Tuberculin in Macaca mulatta

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Science  17 Nov 1972:
Vol. 178, Issue 4062, pp. 757-759
DOI: 10.1126/science.178.4062.757


Delayed hypersensitivity in Macaca mulatta infected with either Schistosoma mansoni or mycobacteria was demonstrated by biopsies of skin test sites. Both dialyzable and nondialyzable leukocyte extracts from infected donors transferred delayed hypersensitivity to recipient monkeys. In two recipients, skin test conversion was associated with in vitro transformation of the recipients' lymphocytes.