Genetic Mapping of a Murine Leukemia Virus-Inducing Locus of AKR Mice

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Science  24 Nov 1972:
Vol. 178, Issue 4063, pp. 860-862
DOI: 10.1126/science.178.4063.860


The chromosomal location of one of the two murine leukemia virus-inducing loci of AKR mice has been determined. The locus, which appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-1-Akv-1. This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-1 locus.