Bone Marrow-Derived Lymphoid Cells (B Cells): Functional Depletion with Cobra Factor and Fresh Serum

See allHide authors and affiliations

Science  24 Nov 1972:
Vol. 178, Issue 4063, pp. 866-867
DOI: 10.1126/science.178.4063.866


Treatment of rat spleen cells with cobra factor and fresh rat serum provided a simple, rapid means of functionally eliminating complement receptor lymphocytes. Cells able to differentiate into plaque-forming cells in a syngeneic, irradiated host were diminished, but cells able to induce a graft-versus-host reaction were not diminished. There was no effect on plaque-forming cells from an immune spleen.