Phosphorylase: A New Isozyme in Rat Hepatic Tumors and Fetal Liver

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Science  24 Nov 1972:
Vol. 178, Issue 4063, pp. 879-881
DOI: 10.1126/science.178.4063.879


A third set of phosphorylase a and b isozymes, distinguishable kinetically and immunologically from liver and muscle forms, is present in various rat hepatomas, and is also present, together with the adult liver form, in fetal rat liver. This is one of several striking examples of suppression of isozymes of adult liver coupled with the appearance of fetal isozymes in hepatomas.