Calcitonin Receptors of Kidney and Bone

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Science  01 Dec 1972:
Vol. 178, Issue 4064, pp. 999-1001
DOI: 10.1126/science.178.4064.999


Receptors for calcitonin, determined by activation of adenylate cyclase, were found in a distribution among zones of the kidney distinct from that of receptors for parathyroid hormone or vasopressin. Competitive binding studies showed that the receptors for calcitonin are similar in kidney and bone and that their high apparent affinity for salmon calcitonin accounts in part for the high biological potency in vivo of salmon calcitonin.