Cat Hemoglobin: pH-Dependent Cooperativity of Oxygen Binding

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Science  08 Dec 1972:
Vol. 178, Issue 4065, pp. 1104-1106
DOI: 10.1126/science.178.4065.1104


Cat hemoglobin has a lower cooperativity and oxygen affinity than most mammalian hemoglobins. In contrast to the usual invariance of cooperativity with pH, a rise in cooperativity with pH is predicted by the allosteric model for low-affinity hemoglobins. Such a pH-dependent cooperativity for cat hemoglobin has been found.