Inhibition of Sperm-Egg Interaction by Specific Antibody

Science  15 Dec 1972:
Vol. 178, Issue 4066, pp. 1211-1213
DOI: 10.1126/science.178.4066.1211


Treatment of hamster ova, in vitro, with ovary specific antibody interferes with sperm-egg interaction by inhibiting sperm attachment to the zona pellucida and subsequent zona penetration. This inhibition results from precipitation of the zona by the specific antibody.