Photoreactivation of Ultraviolet-Induced Chromosomal Aberrations

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Science  05 Jan 1973:
Vol. 179, Issue 4068, pp. 86-88
DOI: 10.1126/science.179.4068.86


Ultraviolet induces only chromatid-type aberrations in synchronized G1 V-79 Chinese hamster and A8W243 Xenopus tissue culture cells. Posttreatment with white light prevents expression of most potential aberrations in the A8 toad cell, which possesses a photoreactivation enzyme. We conclude that the major ultraviolet-induced DNA lesion leading to chromosomal aberrations is the pyrimidine dimer.