Hypothalamic Regulatory Hormones

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Science  26 Jan 1973:
Vol. 179, Issue 4071, pp. 341-350
DOI: 10.1126/science.179.4071.341


The molecular structures of several polypeptides isolated from hypothalamic tissue have been established and the synthesis of these compounds has been achieved. These polypeptides selectively stimulate or inhibit the release of anterior pituitary hormones and melanocyte-stimulating hormone. Various studies indicate their important physiological role and support the concept that some of these polypeptides are hormones. Some synthetic hypothalamic hormones and their derivatives may find important clinical and veterinary applications.