Adenosine 3',5'-Monophosphate in Pancreatic Islets: Glucose-Induced Insulin Release

See allHide authors and affiliations

Science  09 Feb 1973:
Vol. 179, Issue 4073, pp. 569-571
DOI: 10.1126/science.179.4073.569


Glucose-induced release of insulin from perifused rat islets is associated with elevated islet adenosine 3',5'-monophosphate. If values for adenosine 3',5'-monophosphate are compared to insulin release during theophylline or glucose stimulation and theophylline plus glucose stimulation, it suggests a minor role for adenosine 3',5'-monophosphate in directly stimulating insulin release but a prominent role in modulating glucose-induced release of insulin.