Automatic Screening of Biological Specimens by Optical Correlation

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Science  09 Feb 1973:
Vol. 179, Issue 4073, pp. 571-573
DOI: 10.1126/science.179.4073.571


An optical analog correlation technique was used to detect morphologic abnormalities in rat liver cells. The method employs an optical matched filter for correlating a test pathological specimen with a control specimen. Experimental results show appreciable promise that such an optical correlator can be employed as a tool for rapid mass screening of a variety of pathological specimens.