Amyotrophic Lateral Sclerosis: Effect of Serum on Anterior Horn Cells in Tissue Culture

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Science  09 Feb 1973:
Vol. 179, Issue 4073, pp. 579-580
DOI: 10.1126/science.179.4073.579


A high proportion of diluted serums of patients with amyotrophic lateral sclerosis were toxic to the anterior horn cells of the mouse in tissue culture. This is not a general cytotoxicity, since apparently only the neurons were killed. Serums from other degenerative neurological diseases were inactive.