Amphotericin B Methyl Ester Hydrochloride and Amphotericin B: Comparative Acute Toxicity

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Science  09 Feb 1973:
Vol. 179, Issue 4073, pp. 584-585
DOI: 10.1126/science.179.4073.584


In single-dose parenteral studies with mice and dogs, the methyl ester hydrochloride of amphotericin B proved to be significantly less toxic than the parent compound, especially to the kidney.