Reports

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

Science  09 Feb 1973:
Vol. 179, Issue 4073, pp. 588-590
DOI: 10.1126/science.179.4073.588

Abstract

When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the 75Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.

Related Content