Cholesterol: Vitamin C Controls Its Transformation to Bile Acids

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Science  16 Feb 1973:
Vol. 179, Issue 4074, pp. 702-704
DOI: 10.1126/science.179.4074.702


Cholesterol accumulates in the blood serum and in the liver of guinea pigs with chronic latent vitamin C deficiency. The reason for this is the decreased rate of transformation of cholesterol to bile acids in the liver of animals deficient in vitamin C. A significant direct correlation exists between the vitamin C concentration in the liver and the rate of cholesterol transformation to bile acids.