Graft versus Leukemia: Quantification of Adoptive Immunotherapy in Murine Leukemia

Science  23 Feb 1973:
Vol. 179, Issue 4075, pp. 811-813
DOI: 10.1126/science.179.4075.811


Quantification of the antileukemic reactivity of transplanted immunocompetent cells from various allogeneic donors was achieved against a long-passage lymphocytic leukemia of AKR mice. Adoptive immunotherapy was the exclusive antileukemic treatment. Cells from DBA/2 donors exhibited maximal antileukemic effect, inactivating up to an estimated 107 leukemia cells. The cellular events were interpreted by using a theoretical cytokinetic construct.