Activation of Lordotic Responding in Female Rats by Suppression of Serotonergic Activity

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Science  09 Mar 1973:
Vol. 179, Issue 4077, pp. 1010-1011
DOI: 10.1126/science.179.4077.1010


After systemic administration of several serotonergic antagonists, female rats that had been ovariectomized, adrenalectomized, and estrogen-primed showed lordotic responding. Lordosis could also be elicited after direct placement of serotonergic receptor blockers into hypothalamic sites known to contain serotonergic terminals. None of the treatments activated the soliciting component of the estrous behavior pattern of the female rat. It is postulated that the hypothalamus contains serotonergic terminals which suppress lordotic responding.