Opiate Receptor: Demonstration in Nervous Tissue

Science  09 Mar 1973:
Vol. 179, Issue 4077, pp. 1011-1014
DOI: 10.1126/science.179.4077.1011


Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine. Competition for the opiate receptor by various opiates and their antagonists closely parallels their pharmacological potency. The opiate receptor is confined to nervous tissue.

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