SV40 Virus Transformation of Mouse 3T3 Cells Does Not Specifically Enhance Sugar Transport

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Science  23 Mar 1973:
Vol. 179, Issue 4079, pp. 1238-1240
DOI: 10.1126/science.179.4079.1238


The apparent enhancement of 2-deoxy-D-glucose uptake by mouse 3T3 cells accompanying transformation by SV40 virus is not due primarily to an effect on the transport process but to enhanced phosphorylation of the sugar by intracellular kinases. Moreover, the effect is not specifically a function of the presence of the viral genome, but is a reflection of the overall growth rate and physiological state of the cell.