Toxin from Fusarium moniliforme: Effects on Plants and Animals

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Science  30 Mar 1973:
Vol. 179, Issue 4080, pp. 1324-1326
DOI: 10.1126/science.179.4080.1324


A mycotoxin-producing strain of Fusarium moniliforme was isolated from southern leaf blight-damaged corn seed. A water-soluble toxin, subsequently purified from the fungus, had an oral median lethal dose of 4.0 milligrams per kilogram in 1-day-old cockerels. The toxin also produced plant growth-regulating and phytotoxic effects on plant systems. Physical and chemical data presented for the toxin suggest a structurally new toxin. The trivial name "moniliformin" has been assigned to the toxin.