Electrogenic Sodium Pump in Squid Giant Axon

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Science  30 Mar 1973:
Vol. 179, Issue 4080, pp. 1326-1328
DOI: 10.1126/science.179.4080.1326


Squid giant axon possesses a hyperpolarizing electrogenic sodium pump which is stimulated by internal sodium and by external potassium. This conclusion is based on the following observations: strophanthidin depolarizes the membrane and enhances the depolarizing effect of 5 or 10 millimolar external potassium; the magnitude of these effects is directly related to the internal sodium concentration; both effects are abolished by cyanide.