Isolated Adrenal Cortex Cells: Hypersensitivity to Adrenocorticotropic Hormone after Hypophysectomy

See allHide authors and affiliations

Science  30 Mar 1973:
Vol. 179, Issue 4080, pp. 1330-1331
DOI: 10.1126/science.179.4080.1330


Cells from the adrenals of hypophysectomized rats (up to 28 days after operation) require less adrenocorticotropic hormone to induce one-half maximal rate of production of 3',5'-adenosine monophosphate than do cells from the adrenals of intact rats. A corresponding increase in sensitivity is reflected in the steroidogenic response to adrenocorticotropic hormone up to 2 days after hypophysectomy.