Reports

Electrocardiogram Monitoring: Computerized Detection of Ventricular Changes Induced by Drugs

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Science  30 Mar 1973:
Vol. 179, Issue 4080, pp. 1338-1340
DOI: 10.1126/science.179.4080.1338

Abstract

Cardiac arrhythmia was induced in mice by the injection of ouabain, lidocaine, and diphenylhydantoin. Temporal spreading of ventricular electrocardiographic complexes is shown consistently to follow injection of a cardioactive drug and to precede rhythm disturbances. A computerized monitoring technique based on temporal spreading and waveform distortion should find wide clinical and experimental application.