Serotonin: Radioimmunoassay

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Science  30 Mar 1973:
Vol. 179, Issue 4080, pp. 1340-1341
DOI: 10.1126/science.179.4080.1340


The development of a radioimmunoassay for serotonin is described. Serotonin is made antigenic by coupling it to bovine serum albumin. Thrombocyte-free plasma instead of serum from the immunized animals is used for radioimmunoassay. Less than 1 ng serotonin can be measured by this procedure.