Insect Juvenile Hormones: Highly Potent Synthetic Mimics

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Science  30 Mar 1973:
Vol. 179, Issue 4080, pp. 1342-1343
DOI: 10.1126/science.179.4080.1342


The substitution of a 7-alkoxy group for the 6,7-epoxy moiety in aryl terpenoid ethers having high juvenile hormone activity has produced several compounds exceptionally active against Tenebrio molitor. The most potent compound [7-ethoxy-1-(p-ethylphenoxy)-3,7-dimethyl-2-octene, called JH-25] is active at the level of 10 picograms per insect, or about 100 times more active than other promising juvenile hormone mimics so far reported. Compound JH-25 was also active against Tribolium confusum.