Hepatitis B Virus Antigen: Validation and Immunologic Characterization of Low-Titer Serums with 125I-Antibody

See allHide authors and affiliations

Science  13 Apr 1973:
Vol. 180, Issue 4082, pp. 203-205
DOI: 10.1126/science.180.4082.203


Radioimmunnoassay was used to determine the serologic subspecificities of 85 blood donor serums positive for hepatitis B virus-associated antigen. There was complete agreement with results obtained by immunoprecipitatiotn of 43 serums. The remaining 42 serums were negative by immunoprecipitation but followed type-specific immunology by radioimmunoassay, and this served as a validation for authentic hepatitis B virus antigen.