Hyaluronate Inhibition of Chondrogenesis: Antagonism of Thyroxine, Growth Hormone, and Calcitonin

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Science  20 Apr 1973:
Vol. 180, Issue 4083, pp. 302-303
DOI: 10.1126/science.180.4083.302


The formation of cartilage-like aggregates in high-density stationary cultures of trypsinized chick embryo precartilage cells is blocked by low concentrations of hyaluronate. Thyroxine (and triiodothyronine), growth hormone, calcitonin, and adenosine 3',5'-monophosphate prevented this inhibition by hyaluronate, whereas other hormones tested did not.