Enzyme Electrodes

Science  27 Apr 1973:
Vol. 180, Issue 4084, pp. 380-384
DOI: 10.1126/science.180.4084.380


From the discussion of electrodes and enzymes herein, and from the accounts of enzyme electrodes that have appeared in the literature, clinical determinations of certain metabolites and soluble enzymes by means of enzyme electrodes seem quite feasible. Such devices may be made highly specific by the use of appropriate enzymes and a high degree of accuracy can be obtained. Instantaneous and continuous determinations can be made from physiological fluids, and undesirable physiologic responses can theoretically be minimized, thus making long-term clinical monitoring a possibility. Enzyme electrodes may also have a useful lifetime and meet other practical requirements.