Reports

Brain Aluminum Distribution in Alzheimer's Disease and Experimental Neurofibrillary Degeneration

Science  04 May 1973:
Vol. 180, Issue 4085, pp. 511-513
DOI: 10.1126/science.180.4085.511

Abstract

Neurofibrillary degeneration is an important pathological finding in senile and presenile dementia of the Alzheimer type. Experimentally, aluminum induces neurofibrillary degeneration in neurons of higher mammals. Aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease.

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