Pronase Effect on Pancreatic Beta Cell Secretion and Morphology

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Science  11 May 1973:
Vol. 180, Issue 4086, pp. 647-649
DOI: 10.1126/science.180.4086.647


Pronase at low concentration (4 micrograms per milliliter) produces a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.