Anticoagulant-Resistant Rats: Possible Control by the Use of the Chloro Analog of Vitamin K1

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Science  18 May 1973:
Vol. 180, Issue 4087, pp. 741-743
DOI: 10.1126/science.180.4087.741


Strains of wild rats that are resistant to the anticoagulant action of coumarins and derivatives of indandione have been discovered in a number of geographic areas. These rats have now been shown to be more susceptible than normal rats are to the anticoagulant action of the vitamin K antagonist, 2-chloro-3-phytyl-1,4-naphthoquinone. This compound, either alone or in combination with warfarin, would appear to be an effective rodenticide in areas where resistance to the indirect anticoagulants is a problem.