Mucopolysaccharides: Comparison of Chondroitin Sulfate Conformations with Those of Related Polyanions

See allHide authors and affiliations

Science  18 May 1973:
Vol. 180, Issue 4087, pp. 743-745
DOI: 10.1126/science.180.4087.743


X-ray diffraction shows that chondroitin 6-sulfate, and some further rulfated derivatives, can occur in two ordered structures in stretched films. Both structures contain single helices with similar projected disaccharide lengths (9.6 and 9.8 angstroms) but with very different turn angles between successive disaccharides (120 and 45 degrees). In contrast, coaxial double helices of hyaluronates and t-carrageenates have shorter projected disaccharide lengths (8.5 and 8.9 angstroms).