Histamine: Effect on Self-Stimulation

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Science  18 May 1973:
Vol. 180, Issue 4087, pp. 757-758
DOI: 10.1126/science.180.4087.757


When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes.