Segregation of Loci for C-Type Virus Induction in Strains of Mice with High and Low Incidence of Leukemia

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Science  25 May 1973:
Vol. 180, Issue 4088, pp. 865-866
DOI: 10.1126/science.180.4088.865


Multiple genetic loci for induction of murine leukemia viruses are demonstrated in cells of the high leukemic incidence C58 mouse strain. The biologic properties of viruses at C58 inducibility loci are clearly distinguishable from those of viruses activated from mouse cells containing a locus for virus induction of the low leukemia incidence BALB/c strain. These findings are consistent with the hypothesis that the genes for virus induction in normal mouse embryo cells represent viral structural information.