Thyrotropin and Cyclic Nucleotide Effects on Prostaglandin Levels in Isolated Thyroid Cells

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Science  25 May 1973:
Vol. 180, Issue 4088, pp. 872-875
DOI: 10.1126/science.180.4088.872


Thyrotropin increases prostaglandin levels in isolated thyroid cells. Since comparable results were obtained with butyrated cyclic adenosine monophosphate derivatives as well as with the phosphodiesterase inhibitors quazodine and theophylline, it appears that cyclic adenosine monophosphate mediates this effect of thyrotropin. These observations suggest that intracellular prostaglandins play a role in modulating thyrotropin action on thyroid.