Retrograde State Dependent Learning

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Science  25 May 1973:
Vol. 180, Issue 4088, pp. 878-880
DOI: 10.1126/science.180.4088.878


Sodium pentobarbital administered intravenously after acquisition in a one-trial passive avoidance task results in state dependent (drug dissociated) learning in male albino rats. Findings have methodological implications for drug-based research and theoretical implications for drug discrimination studies. Predictions based on a stimulus generalization hypothesis are not supported, whereas those based on an information storage hypothesis are supported.