Isotachysterol3 and 25-Hydroxyisotachysterol3: Analogs of 1,25-Dihydroxyvitamin D3

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Science  01 Jun 1973:
Vol. 180, Issue 4089, pp. 964-966
DOI: 10.1126/science.180.4089.964


Isotachysterol3, 25-hydroxyisotachysterol3, and isovitamin D3 have been synthesized and tested for biological activity. Like 1,25-dihydroxyvitamin D3, isotachysterol3 stimulates intestinal calcium transport and bone calcium mobilization in anephric rats, whereas 25-hydroxyvitamin D3 does not. Although isovitamin D3 is biologically active in normal rats it is inactive in anephric rats.