Enzyme Release from Polymorphonuclear Leukocyte Lysosomes: Regulation by Autonomic Drugs and Cyclic Nucleotides

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Science  15 Jun 1973:
Vol. 180, Issue 4091, pp. 1181-1183
DOI: 10.1126/science.180.4091.1181


Osmotic release of β-glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3',5'-monophosphate, and accelerated by cholinergic agents and guanosine 3',5'-monophosphate. These actions are specific for the sympathetic and parasympathetic neurotransmitters and for the two cyclic nucleotides, as phenylephrine, tyramine, choline, adenosine 5'-monophosphate and guanosine 5'-monophosphate do not inodify lysosomal enzyme release.