Complement-Induced Platelet Protein Alterations

Science  15 Jun 1973:
Vol. 180, Issue 4091, pp. 1183-1185
DOI: 10.1126/science.180.4091.1183


Polypeptides of high molecular weight are deleted from the sedimentable fraction of platelets subjected, while intact, to complement action. These polypeptides, distinct from the previously described thrombin-sensitive protein of this fraction, also diminish after platelets are exposed to thrombin. They may be of importance in the molecular events underlying complement-triggered changes in platelet function.