Axonal Transport of Dopamine-β-Hydroxylase by Human Sural Nerves in vitro

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Science  22 Jun 1973:
Vol. 180, Issue 4092, pp. 1295-1297
DOI: 10.1126/science.180.4092.1295


Dopamine-β-hydroxylase activity accumulated above a ligature on biopsy samples of normal human sural nerves incubated in vitro. The rate of accumulation indicated that this enzyme was transported distally at a velocity of 2 millimeters per hour. Axoplasmic transport of dopamine-β-hydroxylase was greatly reduced in sural nerves from a few patients with peripheral neuropathies.