Crystallization of NADP-Specific Isocitrate Dehydrogenase

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Science  06 Jul 1973:
Vol. 181, Issue 4094, pp. 59-60
DOI: 10.1126/science.181.4094.59


The first crystalline preparation of isocitrate dehydrogenase specific for nicotinamide adenine dinucleotide phosphate has been obtained with enzyme isolated from Escherichia coli. Scanning electron microscopy was employed to elucidate the structure of the crystals, which were found to exist as regular octahedrons ranging in size from 5 to 90 micrometers.