Regulation of Muscle Acetylcholine Sensitivity by Muscle Activity in Cell Culture

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Science  06 Jul 1973:
Vol. 181, Issue 4094, pp. 76-78
DOI: 10.1126/science.181.4094.76


Muscle in tissue culture provides a good system for studying longterm changes in surface membrane acetylcholine sensitivity. Muscle fibers stimulated intermittently over prolonged periods are less sensitive to iontophoretically applied acetylcholine and bind less 125I-labeled α-bungarotoxin than inactive fibers.