Lysergic Acid Diethylamide: Radioimmunoassay

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Science  13 Jul 1973:
Vol. 181, Issue 4095, pp. 165-166
DOI: 10.1126/science.181.4095.165


A radioimmnunoassay for d-lysergic acid diethylamide (LSD) is described. Antibodies to LSD were obtained by immunizing rabbits with a conjugate of LSD and human serum albumin. The specificity of the antibody was shown by competitive binding studies. The method has been used to detect the presence of LSD in human urines. Picogram amounts can be measured by this assay.