Superinduction of Endogenous Type C Virus by 5-Bromodeoxyuridine from Transformed Mouse Clones

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Science  03 Aug 1973:
Vol. 181, Issue 4098, pp. 443-444
DOI: 10.1126/science.181.4098.443


Certain transformed subclones of the mouse cell line BALB/3T3 release 5 to 15 times more type C virus per cell than the parent cell line after treatment with 5-bromodeoxyuridine. Virus release begins within 8 hours and exponentially increases for the first 24 to 48 hours. Superinducibility is associated with the transformed phenotype.