Virus-Free Adenocarcinoma of the Frog (Summer Phase Tumor) Transcribes Lucké Tumor Herpesvirus-Specific RNA

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Science  03 Aug 1973:
Vol. 181, Issue 4098, pp. 448-449
DOI: 10.1126/science.181.4098.448


[3H]RNA isolated from "virus-free," summer phase, renal adenocarcinomas of Rana pipiens labeled with [3H]uridine hybridizes with DNA of herpesvirus particles isolated from the winter phase Lucké tumor. Transcription of the herpesvirus genome in virus-free tumors provides additional evidence for the viral etiology of this tumor.