Infertility in Female Rabbits Immunized with Lactate Dehydrogenase X

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Science  03 Aug 1973:
Vol. 181, Issue 4098, pp. 458-459
DOI: 10.1126/science.181.4098.458


Immunization of female rabbits with the sperm-specific lactate dehydrogenase (LDH-X) resulted in a highly significant reduction of pregnancies compared to nonimmunized controls. This is the first demonstration of immunosuppression of fertility by a crystalline protein shown to be strictly homogeneous by ultracentrifugation, polyacrylamide gel electrophoresis, immunodiffusion, and micro complement fixation.