Insecticide Inhibition of 5α-Dihydrotestosterone Binding in the Rat Ventral Prostate

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Science  17 Aug 1973:
Vol. 181, Issue 4100, pp. 659-661
DOI: 10.1126/science.181.4100.659


The chlorinated hydrocarbon insecticides dieldrin and o,p'-DDT inhibit binding of 5α-dihydrotestosterone to specific receptor proteins in rat prostate cytosol. Dieldrin is less inhibitory than o,p'-DDT.