Brain Calcium: Role in Temperature Regulation

Science  17 Aug 1973:
Vol. 181, Issue 4100, pp. 663-664
DOI: 10.1126/science.181.4100.663


Perfusion of the preoptic-anterior hypothalamus with excess calcium ion in ground squirrels produces a drop in core temperature. The magnitude of the drop is directly dependent on ambient temperature. Respiration, heart rate, and oxygen consumption are also reduced during perfusion of calcium ion. It is concluded that the depression of body temperature during calcium ion perfusion is due to generalized depression of the neurons of the preoptic-anterior hypothalamus.